This document identifies the full set of changes in QA-MISRA 22.10 from version 22.04 onwards. This release includes new Rule Sets and Checkers against the AUTOSAR and CERT standards for C/C++. Checks have been improved to avoid double reporting and lower false positives and false negatives. Other checks improve the quality of rule implementations. The usability of graphical code insight views has also been enhanced in this version. QA-MISRA 22.10 also contains several other productivity and flexibility enhancements as well as fixes.